AlphaGenome 2: Deciphering how cells read DNA to better understand disease

Google DeepMind announced AlphaGenome 2, a conditional DNA sequence model trained on over 107 million individual cell profiles across 68 tissues that predicts how genetic variants affect gene expression in specific human cell types and states. The model identified nearly twice as many causal variants (30% vs. 16%) and directional gene effects (43% vs. 23%) as the original AlphaGenome fine-tuned on single-cell data on the TenK10K immune cell dataset, and can generalize to unseen single-cell experiments without retraining. It is available for non-commercial research via the AlphaGenome API and in private preview for commercial research.